NANOEMULGEL BASED ON GUAR GUM AND PLURONIC® F127 CONTAINING ENCAPSULATED HESPERIDIN WITH ANTIOXIDANT POTENTIAL

Introduction: The development of antioxidant cosmetic products based on natural added to nanotechnology is gaining more and prominence. However, some these actives are hydrophobic, which makes their placement in aqueous systems impossible. As a strategy deliver hydrophobic hydrophilic gels, nanoemulgels have been presented.
 Materials Methods: present study aimed prepare an nanoemulgel guar gum Pluronic® F127 as for the delivery hesperidin, flavonoid. A nanoemulsion was prepared characterized be incorporated into gel. formed evaluated rheology activity.
 Results Discussion: had particle size 192 ± 4 nm, polydispersity index 0.11 0.01 zeta potential -32.1 0.9 mV. encapsulation efficiency obtained 99.35% rheological showed satisfactory gel characteristics topical use. nanoemulsions by DPPH method presented IC50 value 14.4 ±1.3 μg mL-1 expressed hesperidin equivalent 17.4 mg nanoemulgel. formulated delivered hesperidinsuccessfully without affecting its properties, showing promise anti-aging